HRT Replacement Therapy and Oral Contraceptives May Protect Against Brain Aneurysms!

HRT replacement therapyResults from a new study suggest that oral contraceptives and HRT replacement therapy may yield an additional benefit against the formation and rupture of brain aneurysms in women.

A brain aneurysm, also called cerebral aneurysm, is an abnormal bulge or ballooning in a blood vessel supplying your brain. The weakened area forms a sac or small balloon that fills with blood. Usually brain aneurysms occur at branching points of arteries.

Brain aneurysms can rupture and cause bleeding into your brain. Usually this occurs in the area between your brain and the surrounding membrane, called the subarachnoid space, causing a hemorrhage. Many small aneurysms, especially those located on the arteries in the front part of your brain, have a low risk of rupture. However, ruptured brain aneurysms can lead to stroke and death.

This new study on HRT replacement therapy and oral contraceptives is a first-of-its-kind study by a neurointerventional expert from Rush University Medical Center and was presented at the Society of Neurointerventional Surgery’s (SNIS) 7th annual meeting.

According to the lead author of the study, Dr. Michael Chen, the case-controlled study was initiated due to the observation that in the two largest brain aneurysm trials to date, cerebral aneurysms occurred most frequently (70%) in women of menopause age at a time of life coinciding with a severe drop in estrogen levels.

The study on HRT replacement therapy was conducted over a two-year period from 2008-2010, the case group consisted of 60 women with both ruptured and unruptured aneurysms with an age range of 31-80 and was compared against a control group of 4,682 random females that represented population averages.

The team next plans to study the effects of estrogen on the blood vessels of the brain.

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